Sant, DW;
Sinclair, M;
Mungall, CJ;
Schulz, S;
Zerbino, D;
Lovering, RC;
Logie, C;
(2021)
Sequence Ontology terminology for gene regulation.
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
, 1864
(10)
, Article 194745. 10.1016/j.bbagrm.2021.194745.
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Abstract
The Sequence Ontology (SO) is a structured, controlled vocabulary that provides terms and definitions for genomic annotation. The Gene Regulation Ensemble Effort for the Knowledge Commons (GREEKC) initiative has gathered input from many groups of researchers, including the SO, the Gene Ontology (GO), and gene regulation experts, with the goal of curating information about how gene expression is regulated at the molecular level. Here we discuss recent updates to the SO reflecting current knowledge. We have developed more accurate human-readable terms (also known as classes), including new definitions, and relationships related to the expression of genes. New findings continue to give us insight into the biology of gene regulation, including the order of events, and participants in those events. These updates to the SO support logical reasoning with the current understanding of gene expression regulation at the molecular level.
Type: | Article |
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Title: | Sequence Ontology terminology for gene regulation |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1016/j.bbagrm.2021.194745 |
Publisher version: | https://doi.org/10.1016/j.bbagrm.2021.194745 |
Language: | English |
Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
Keywords: | Gene regulation, Ontology |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science |
URI: | https://discovery.ucl.ac.uk/id/eprint/10133092 |
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