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Structural Brain Correlates in Major Depression, Anxiety Disorders and Post-traumatic Stress Disorder: A Voxel-Based Morphometry Meta-analysis

Serra-Blasco, M; Radua, J; Soriano-Mas, C; Gómez-Benlloch, A; Porta-Casteràs, D; Carulla-Roig, M; Albajes-Eizagirre, A; ... Cardoner, N; + view all (2021) Structural Brain Correlates in Major Depression, Anxiety Disorders and Post-traumatic Stress Disorder: A Voxel-Based Morphometry Meta-analysis. Neuroscience and Biobehavioral Reviews , 129 pp. 269-281. 10.1016/j.neubiorev.2021.07.002. Green open access

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Abstract

The high comorbidity of Major Depressive Disorder (MDD), Anxiety Disorders (ANX), and Posttraumatic Stress Disorder (PTSD) has hindered the study of their structural neural correlates. The authors analyzed specific and common grey matter volume (GMV) characteristics by comparing them with healthy controls (HC). The meta-analysis of voxel-based morphometry (VBM) studies showed unique GMV diminutions for each disorder (p < 0.05, corrected) and less robust smaller GMV across diagnostics (p < 0.01, uncorrected). Pairwise comparison between the disorders showed GMV differences in MDD versus ANX and in ANX versus PTSD. These results endorse the hypothesis that unique clinical features characterizing MDD, ANX, and PTSD are also reflected by disorder specific GMV correlates.

Type: Article
Title: Structural Brain Correlates in Major Depression, Anxiety Disorders and Post-traumatic Stress Disorder: A Voxel-Based Morphometry Meta-analysis
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neubiorev.2021.07.002
Publisher version: https://doi.org/10.1016/j.neubiorev.2021.07.002
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Anxiety disorders, Comorbidities, Gray matter volume, Major depressive disorder, Meta-analysis, Neuropsychiatry, Posttraumatic stress disorder, Structural neuroimaging
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/10133008
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