Keefe, D;
(2021)
Inherent Mosaicism and Extensive Mutation of Human Placentas.
Obstetrical and Gynecological Survey
, 76
(6)
pp. 341-342.
10.1097/OGX.0000000000000935.
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Abstract
Approximately 1% to 2% of pregnancies involve chromosomal aberrations confined to the placenta. During the first few days of embryogenesis when fetal and placental lineages diverge, clonal expansion and mosaicism may occur, representing a potential pathological divergence from normal clonal dynamics of early embryogenesis. Mutations acquired during cell division may be identified and used to reconstruct embryonic lineage relationships that can reveal specific mutagenic processes affecting a tissue.
| Type: | Article |
|---|---|
| Title: | Inherent Mosaicism and Extensive Mutation of Human Placentas |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1097/OGX.0000000000000935 |
| Publisher version: | https://doi.org/10.1097/OGX.0000000000000935 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10132991 |
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