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Understanding the impact of immune-mediated selection on lung cancer evolution

Rosenthal, R; Swanton, C; McGranahan, N; (2021) Understanding the impact of immune-mediated selection on lung cancer evolution. British Journal of Cancer , 124 (10) pp. 1615-1617. 10.1038/s41416-020-01232-6. Green open access

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Abstract

Summary Understanding how a tumour evolves and avoids immune recognition is paramount to improving cancer immunotherapy and patient outcome. Here we examine our recent integration of multi-region genomic, transcriptomic, epigenomic, pathology, and clinical data, highlight the need for a systematic examination of immune escape mechanisms, and discuss implications for immunotherapy approaches.

Type: Article
Title: Understanding the impact of immune-mediated selection on lung cancer evolution
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41416-020-01232-6
Publisher version: https://doi.org/10.1038/s41416-020-01232-6
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Oncology, Cancer genomics, Cancer microenvironment, Non-small-cell lung cancer
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: https://discovery.ucl.ac.uk/id/eprint/10132894
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