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Reappraising the role of the vagus nerve in GLP-1-mediated regulation of eating.

Brierley, DI; de Lartigue, G; (2021) Reappraising the role of the vagus nerve in GLP-1-mediated regulation of eating. British Journal of Pharmacology 10.1111/bph.15603. (In press). Green open access

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Abstract

Here, we provide a focused review of the evidence for the roles of the vagus nerve in mediating the regulatory effects of peripherally and centrally produced GLP-1 on eating behaviour and energy balance. We particularly focus on recent studies which have used selective genetic, viral, and transcriptomic approaches to provide important insights into the anatomical and functional organisation of GLP-1-mediated gut-brain signalling pathways. A number of these studies have challenged canonical ideas of how GLP-1 acts in the periphery and the brain to regulate eating behaviour, with important implications for the development of pharmacological treatments for obesity.

Type: Article
Title: Reappraising the role of the vagus nerve in GLP-1-mediated regulation of eating.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/bph.15603
Publisher version: https://doi.org/10.1111/bph.15603
Language: English
Additional information: © 2021 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: Eating, feeding, glucagon-like peptide-1, neuropeptide, obesity, preproglucagon, vagus nerve
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: https://discovery.ucl.ac.uk/id/eprint/10132845
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