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Regulatory T cells enhance Th17 migration in psoriatic arthritis which is reversed by anti-TNF

Nguyen, Dao X; Baldwin, Helen M; Ezeonyeji, Amara N; Rohan Butt, Mohammed; Ehrenstein, Michael R; (2021) Regulatory T cells enhance Th17 migration in psoriatic arthritis which is reversed by anti-TNF. iScience , 24 (9) , Article 102973. 10.1016/j.isci.2021.102973. Green open access

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Abstract

Regulatory T cells (Treg) prevent the migration of effector T cells toward sites of inflammation, thereby limiting disease progression. We investigated this aspect of Treg function using psoriatic arthritis (PsA) as an exemplar of chronic inflammation. Patients with PsA had an increased Th17:Treg ratio which was reversed by anti-tumor necrosis factor (TNF) therapy. Utilizing an in vitro migration assay, Treg from patients with PsA treated with conventional therapy paradoxically boosted CCR6⁺ effector T-cell (a surrogate for Th17) migration toward CCL20. In contrast, Treg from patients with PsA treated with anti-TNF suppressed CCL20-driven effector T-cell migration. The boosting effect of TNF blockade upon Treg suppression of migration was accompanied by increased effector T-cell CCL20 production and enhanced interaction between Treg and effector T cells. This study provides mechanistic insight into Treg modulation of effector T-cell migration in patients with chronic inflammation and how this can be targeted by therapy.

Type: Article
Title: Regulatory T cells enhance Th17 migration in psoriatic arthritis which is reversed by anti-TNF
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.isci.2021.102973
Publisher version: https://doi.org/10.1016/j.isci.2021.102973
Language: English
Additional information: © The Author(s), 2021. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10132740
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