Gómez-López, S;
Whiteman, ZE;
Janes, SM;
(2021)
Mapping lung squamous cell carcinoma pathogenesis through in vitro and in vivo models.
Communications Biology
, 4
(1)
, Article 937. 10.1038/s42003-021-02470-x.
Preview |
Text
s42003-021-02470-x.pdf - Published Version Download (1MB) | Preview |
Abstract
Lung cancer is the main cause of cancer death worldwide, with lung squamous cell carcinoma (LUSC) being the second most frequent subtype. Preclinical LUSC models recapitulating human disease pathogenesis are key for the development of early intervention approaches and improved therapies. Here, we review advances and challenges in the generation of LUSC models, from 2D and 3D cultures, to murine models. We discuss how molecular profiling of premalignant lesions and invasive LUSC has contributed to the refinement of in vitro and in vivo models, and in turn, how these systems have increased our understanding of LUSC biology and therapeutic vulnerabilities.
| Type: | Article |
|---|---|
| Title: | Mapping lung squamous cell carcinoma pathogenesis through in vitro and in vivo models |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s42003-021-02470-x |
| Publisher version: | https://doi.org/10.1038/s42003-021-02470-x |
| Language: | English |
| Additional information: | © 2021 Springer Nature Limited. This article is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Cancer genetics, Cancer models, Non-small-cell lung cancer |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10132656 |
Archive Staff Only
 |
View Item |
