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Neuropsychological Deficits in Posterior Cortical Atrophy and Typical Alzheimer’s Disease: A Meta-Analytic Review

North, C; Desai, R; Saunders, R; Suárez-González, A; Bamiou, D; Costafreda, SG; de Haan, G; ... Stott, J; + view all (2021) Neuropsychological Deficits in Posterior Cortical Atrophy and Typical Alzheimer’s Disease: A Meta-Analytic Review. Cortex 10.1016/j.cortex.2021.07.011.

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Abstract

Aims To identify cognitive tests that best differentiate between Posterior Cortical Atrophy (PCA) and typical Alzheimer’s Disease (tAD), as well as PCA and healthy control (HC) participants. Method Medline, PsycInfo and Web of Science were systematically searched using terms related to PCA, tAD, and cognitive testing. Seventeen studies were identified, including 441 PCA, 391 tAD, and 284 HC participants. Standardised effect sizes of mean scores were calculated to measure performance differences on cognitive tests for PCA vs. tAD and PCA vs. HC groups. Meta-analyses used a random effects model. Results The most discriminating cognitive tests for PCA and tAD presentations were measures of visuospatial function and verbal memory. Large, significant effect sizes were produced for all measures of visuospatial function, most notably for Rey-Osterrieth Copy (Hedges’ g = -2.79), VOSP Fragmented letters (Hedges’ g = -1.73), VOSP Dot Counting (Hedges’ g = -1.74), and VOSP Cube Analysis (Hedges’ g = -1.98). For measures of verbal memory, the RAVLT delay and Digit Span Backwards produced significant medium effects (Hedges’ g = 0.62 and -0.56, respectively). Conclusion Establishing a common framework for testing individuals with PCA has important implications for diagnosis and treatment, and forms a practical objective for future research. Findings from this meta-analysis suggest that measures of visuospatial function and verbal memory would form an important part of this framework.

Type: Article
Title: Neuropsychological Deficits in Posterior Cortical Atrophy and Typical Alzheimer’s Disease: A Meta-Analytic Review
DOI: 10.1016/j.cortex.2021.07.011
Publisher version: https://doi.org/10.1016/j.cortex.2021.07.011
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: PCA, AD, neuropsychology, cognitive testing
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10132556
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