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Cerebellar granule cell axons support high-dimensional representations

Lanore, F; Cayco-Gajic, NA; Gurnani, H; Coyle, D; Silver, RA; (2021) Cerebellar granule cell axons support high-dimensional representations. Nature Neuroscience , 24 pp. 1142-1150. 10.1038/s41593-021-00873-x. Green open access

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Abstract

In classical theories of cerebellar cortex, high-dimensional sensorimotor representations are used to separate neuronal activity patterns, improving associative learning and motor performance. Recent experimental studies suggest that cerebellar granule cell (GrC) population activity is low-dimensional. To examine sensorimotor representations from the point of view of downstream Purkinje cell ‘decoders’, we used three-dimensional acousto-optic lens two-photon microscopy to record from hundreds of GrC axons. Here we show that GrC axon population activity is high dimensional and distributed with little fine-scale spatial structure during spontaneous behaviors. Moreover, distinct behavioral states are represented along orthogonal dimensions in neuronal activity space. These results suggest that the cerebellar cortex supports high-dimensional representations and segregates behavioral state-dependent computations into orthogonal subspaces, as reported in the neocortex. Our findings match the predictions of cerebellar pattern separation theories and suggest that the cerebellum and neocortex use population codes with common features, despite their vastly different circuit structures.

Type: Article
Title: Cerebellar granule cell axons support high-dimensional representations
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41593-021-00873-x
Publisher version: https://doi.org/10.1038/s41593-021-00873-x
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, VESICULAR GLUTAMATE TRANSPORTERS, INTERNAL-MODELS, MOTOR CORTEX, RAT, INFORMATION, DIVERSITY, BEHAVIOR, INPUTS, AREAS, 3D
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: https://discovery.ucl.ac.uk/id/eprint/10132513
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