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Radiation dose enhancement in megavoltage radiation therapy using au, gd, pt, ag, and bi nanoparticles of various concentration level

Abolaban, F; Nisbet, A; (2022) Radiation dose enhancement in megavoltage radiation therapy using au, gd, pt, ag, and bi nanoparticles of various concentration level. Biointerface Research in Applied Chemistry , 12 (2) pp. 2404-2414. 10.33263/BRIAC122.24042414. (In press). Green open access

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Abstract

A digital phantom was created from a CT scan of a patient’s head and employed together with GATE 8.2 Monte Carlo modeling of a linear accelerator of nominal 6 MV energy to simulate an irradiation geometry for a typical tumor volume centrally within the brain region. Although simplistic in arrangement, this setup was considered appropriate to demonstrate the dose enhancements that may be expected for megavoltage external beam radiation therapy for nanoparticles (NP) of different elemental composition and concentration. Ag, Gd, Pt, Au and Bi were modeled in concentrations varying from 15 mg NP / gram tissue to 70 mg NP / gram tissue. The maximum Average Dose Enhancement Factor (ADEF) to the Gross Tumour Volume (GTV) observed was 3 % for 70 mg NP / gram tissue of Bi.

Type: Article
Title: Radiation dose enhancement in megavoltage radiation therapy using au, gd, pt, ag, and bi nanoparticles of various concentration level
Open access status: An open access version is available from UCL Discovery
DOI: 10.33263/BRIAC122.24042414
Publisher version: http://dx.doi.org/10.33263/BRIAC122.24042414
Language: English
Additional information: © 2021 by the authors. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Keywords: dose enhancement; GATE Monte Carlo; nanoparticles; dosimetry
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10132473
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