Trapp, S;
Brierley, DI;
(2021)
Brain GLP-1 and the regulation of food intake: GLP-1 action in the brain and its implications for GLP-1 receptor agonists in obesity treatment.
British Journal Pharmacology
10.1111/bph.15638.
(In press).
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Abstract
This review considers the similarities and differences between the physiological systems regulated by gut-derived and neuronally-produced GLP-1. It addresses the questions of whether peripheral and central GLP-1 sources constitute separate, linked, or redundant systems, whether the brain GLP-1 system consists of disparate sections or is a homogenous entity, and it explores the implications of the answers to these questions for the use of GLP-1 receptor agonists as anti-obesity drugs.
| Type: | Article |
|---|---|
| Title: | Brain GLP-1 and the regulation of food intake: GLP-1 action in the brain and its implications for GLP-1 receptor agonists in obesity treatment |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/bph.15638 |
| Publisher version: | https://doi.org/10.1111/bph.15638 |
| Language: | English |
| Additional information: | © 2021 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10132459 |
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