Ju, C;
Wong, ICK;
Lau, WCY;
Man, KKC;
Brauer, R;
Ma, T-T;
Alsharif, A;
... Wei, L; + view all
(2021)
Global trends in symptomatic medication use against dementia in 66 countries/regions from 2008 to 2018.
European Journal of Neurology
, 28
(12)
pp. 3979-3989.
10.1111/ene.15053.
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Abstract
Background and purpose: The aim was to determine trends and patterns of symptomatic medication used against dementia in 66 countries and regions. Methods: This was a cross-sectional study that used the wholesale data from the IQVIA Multinational Integrated Data Analysis System database. Sale data for symptomatic medication against dementia from 66 countries and regions from 2008 to 2018 were analysed and stratified by income level (low/middle-income countries [LMICs], n = 27; high-income countries [HICs], n = 37; regions, n = 2). The medication use volume was estimated by defined daily dose (DDD) per 1000 inhabitants per day (World Health Organization DDD harmonized the size, strength and form of each pack and reflects average dosing). Changes in medication use over time were quantified as percentage changes in compound annual growth rates (CAGRs). Results: Total symptomatic medication against dementia sales increased from 0.85 to 1.33 DDD per 1000 inhabitants per day between 2008 and 2018 (LMICs 0.094–0.396; HICs 3.88–5.04), which is an increase of CAGR of 4.53% per year. The increase was mainly driven by the LMICs (CAGR = 15.42%) in comparison to the HICs (CAGR = 2.65%). The overall medication use from 2008 to 2018 increased for all four agents: memantine (CAGR = 8.51%), rivastigmine (CAGR = 6.91%), donepezil (CAGR = 2.72%) and galantamine (CAGR = 0.695%). In 2018, the most commonly used medication globally was donepezil, contributing to 49.8% of total use volume, followed by memantine (32.7%), rivastigmine (11.24%) and galantamine (6.36%). Conclusion: There was an increasing trend in the use of symptomatic medications against dementia globally, but the use remained low in LMICs. Interventions may be needed to support the medication use in some countries.
| Type: | Article |
|---|---|
| Title: | Global trends in symptomatic medication use against dementia in 66 countries/regions from 2008 to 2018 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/ene.15053 |
| Publisher version: | https://doi.org/10.1111/ene.15053 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | acetylcholinesterase inhibitor, Alzheimer's disease, dementia, epidemiology, global neurology, memantine |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Practice and Policy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10132435 |
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