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Development of a fixed module repertoire for the analysis and interpretation of blood transcriptome data

Altman, MC; Rinchai, D; Baldwin, N; Toufiq, M; Whalen, E; Garand, M; Syed Ahamed Kabeer, B; ... Chaussabel, D; + view all (2021) Development of a fixed module repertoire for the analysis and interpretation of blood transcriptome data. Nature Communications , 12 , Article 4385. 10.1038/s41467-021-24584-w. Green open access

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Abstract

As the capacity for generating large-scale molecular profiling data continues to grow, the ability to extract meaningful biological knowledge from it remains a limitation. Here, we describe the development of a new fixed repertoire of transcriptional modules, BloodGen3, that is designed to serve as a stable reusable framework for the analysis and interpretation of blood transcriptome data. The construction of this repertoire is based on co-clustering patterns observed across sixteen immunological and physiological states encompassing 985 blood transcriptome profiles. Interpretation is supported by customized resources, including module-level analysis workflows, fingerprint grid plot visualizations, interactive web applications and an extensive annotation framework comprising functional profiling reports and reference transcriptional profiles. Taken together, this well-characterized and well-supported transcriptional module repertoire can be employed for the interpretation and benchmarking of blood transcriptome profiles within and across patient cohorts. Blood transcriptome fingerprints for the 16 reference cohorts can be accessed interactively

Type: Article
Title: Development of a fixed module repertoire for the analysis and interpretation of blood transcriptome data
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41467-021-24584-w
Publisher version: https://doi.org/10.1038/s41467-021-24584-w
Language: English
Additional information: This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10132430
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