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Structure-function specialisation of the interfascicular matrix in the human achilles tendon

Patel, D; Zamboulis, DE; Spiesz, EM; Birch, HL; Clegg, PD; Thorpe, CT; Screen, HRC; (2021) Structure-function specialisation of the interfascicular matrix in the human achilles tendon. Acta Biomaterialia 10.1016/j.actbio.2021.07.019. (In press). Green open access

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Abstract

Tendon consists of highly aligned collagen-rich fascicles surrounded by interfascicular matrix (IFM). Some tendons act as energy stores to improve locomotion efficiency, but such tendons commonly obtain debilitating injuries. In equine tendons, energy storing is achieved primarily through specialisation of the IFM. However, no studies have investigated IFM structure-function specialisation in human tendons. Here, we compare the human positional anterior tibial tendon and energy storing Achilles tendons, testing the hypothesis that the Achilles tendon IFM has specialised composition and mechanical properties, which are lost with ageing. Data demonstrate IFM specialisation in the energy storing Achilles, with greater elasticity and fatigue resistance than in the positional anterior tibial tendon. With ageing, alterations occur predominantly to the proteome of the Achilles IFM, which are likely responsible for the observed trends towards decreased fatigue resistance. Knowledge of these key energy storing specialisations and their changes with ageing offers crucial insight towards developing treatments for tendinopathy.

Type: Article
Title: Structure-function specialisation of the interfascicular matrix in the human achilles tendon
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.actbio.2021.07.019
Publisher version: https://doi.org/10.1016/j.actbio.2021.07.019
Language: English
Additional information: © 2021 The Author(s). Published by Elsevier Ltd on behalf of Acta Materialia Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Keywords: Anterior tibialis tendon; Fascicles; Interfascicular matrix; Mechanical testing; Mass spectrometry; Ageing
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science
URI: https://discovery.ucl.ac.uk/id/eprint/10132255
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