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Cytokine release syndrome and associated neurotoxicity in cancer immunotherapy

Morris, EC; Neelapu, SS; Giavridis, T; Sadelain, M; (2022) Cytokine release syndrome and associated neurotoxicity in cancer immunotherapy. Nature Reviews Immunology , 22 pp. 85-96. 10.1038/s41577-021-00547-6. Green open access

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Abstract

A paradigm shift has recently occurred in the field of cancer therapeutics. Traditional anticancer agents, such as chemotherapy, radiotherapy and small-molecule drugs targeting specific signalling pathways, have been joined by cellular immunotherapies based on T cell engineering. The rapid adoption of novel, patient-specific cellular therapies builds on scientific developments in tumour immunology, genetic engineering and cell manufacturing, best illustrated by the curative potential of chimeric antigen receptor (CAR) T cell therapy targeting CD19-expressing malignancies. However, the clinical benefit observed in many patients may come at a cost. In up to one-third of patients, significant toxicities occur that are directly associated with the induction of powerful immune effector responses. The most frequently observed immune-mediated toxicities are cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome. This Review discusses our current understanding of their pathophysiology and clinical features, as well as the development of novel therapeutics for their prevention and/or management.

Type: Article
Title: Cytokine release syndrome and associated neurotoxicity in cancer immunotherapy
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41577-021-00547-6
Publisher version: https://doi.org/10.1038/s41577-021-00547-6
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Cytokines, Immunotherapy, Tumour immunology
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
URI: https://discovery.ucl.ac.uk/id/eprint/10132109
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