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An integrated bidirectional multi-channel opto-electro arbitrary waveform stimulator for treating motor neurone disease

Jiang, D; Wu, Y; Almarri, N; Habibollahi, M; Liu, F; Bryson, JB; Greensmith, L; (2021) An integrated bidirectional multi-channel opto-electro arbitrary waveform stimulator for treating motor neurone disease. In: 2021 IEEE International Symposium on Circuits and Systems (ISCAS). IEEE Green open access

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Abstract

This paper presents a prototype integrated bidirectional stimulator ASIC capable of mixed opto-electro stimulation and electrophysiological signal recording. The development is part of the research into a fully implantable device for treating motor neurone disease using optogenetics and stem cell technology. The ASIC consists of 4 stimulator units, each featuring 16-channel optical and electrical stimulation using arbitrary current waveforms with an amplitude up to 16 mA and a frequency from 1.5 Hz to 50 kHz, and a recording front-end with a programmable bandwidth of 1 Hz to 4 kHz, and a programmable amplifier gain up to 74 dB. The ASIC was implemented in a 0.18μm CMOS technology. Simulated performance in stimulation and recording is presented.

Type: Proceedings paper
Title: An integrated bidirectional multi-channel opto-electro arbitrary waveform stimulator for treating motor neurone disease
Event: 2021 IEEE International Symposium on Circuits and Systems
ISBN-13: 9781728192017
Open access status: An open access version is available from UCL Discovery
DOI: 10.1109/ISCAS51556.2021.9401220
Publisher version: https://doi.org/10.1109/ISCAS51556.2021.9401220
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Electronic and Electrical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10132083
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