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Quantitative assessment of structural and functional changes in temporal lobe epilepsy with hippocampal sclerosis

Mo, J; Zhao, B; Adler, S; Zhang, J; Shao, X; Ma, Y; Sang, L; ... Zhang, K; + view all (2021) Quantitative assessment of structural and functional changes in temporal lobe epilepsy with hippocampal sclerosis. Quantitative Imaging in Medicine and Surgery , 11 (5) pp. 1782-1796. 10.21037/qims-20-624. Green open access

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Abstract

Background: Magnetic resonance imaging (MRI) changes in hippocampal sclerosis (HS) could be subtle in a significant proportion of mesial temporal lobe epilepsy (mTLE) patients. In this study, we aimed to document the structural and functional changes in the hippocampus and amygdala seen in HS patients. Methods: Quantitative features of the hippocampus and amygdala were extracted from structural MRI data in 66 mTLE patients and 28 controls. Structural covariance analysis was undertaken using volumetric data from the amygdala and hippocampus. Functional connectivity (FC) measured using resting intracranial electroencephalography (EEG) was analyzed in 22 HS patients and 16 non-HS disease controls. Results: Hippocampal atrophy was present in both MRI-positive and MRI-negative HS groups (Mann-Whitney U: 7.61, P<0.01; Mann-Whitney U: 6.51, P<0.01). Amygdala volumes were decreased in the patient group (Mann-Whitney U: 2.92, P<0.05), especially in MRI-negative HS patients (Mann-Whitney U: 2.75, P<0.05). The structural covariance analysis showed the normalized volumes of the amygdala and hippocampus were tightly coupled in both controls and HS patients (ρSpearman =0.72, P<0.01). FC analysis indicated that HS patients had significantly increased connectivity (Student’s t: 2.58, P=0.03) within the hippocampus but decreased connectivity between the hippocampus and amygdala (Student’s t: 3.33, P=0.01), particularly for MRI-negative HS patients. Conclusions: Quantitative structural changes, including hippocampal atrophy and temporal pole blurring, are present in both MRI-positive and MRI-negative HS patients, suggesting the potential usefulness of incorporating quantitative analyses into clinical practice. HS is characterized by increased intra-hippocampal EEG synchronization and decreased coupling between the hippocampus and amygdala.

Type: Article
Title: Quantitative assessment of structural and functional changes in temporal lobe epilepsy with hippocampal sclerosis
Open access status: An open access version is available from UCL Discovery
DOI: 10.21037/qims-20-624
Publisher version: http://dx.doi.org/10.21037/qims-20-624
Language: English
Additional information: Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the noncommercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.
Keywords: Hippocampal sclerosis (HS); quantitative structural analysis; functional connectivity (FC); mesial temporal lobe epilepsy (mTLE)
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10132045
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