Brinkmalm, G;
Zetterberg, H;
(2021)
The phosphorylation cascade hypothesis of Alzheimer’s disease.
Nature Aging
, 1
(6)
pp. 498-499.
10.1038/s43587-021-00077-9.
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Abstract
Alzheimer’s disease (AD) is characterized by amyloid-β (Aβ)-induced phosphorylation of the axon-stabilizing tau protein, which causes neurodegeneration. Here, Morshed et al. show that deregulated phosphorylation in AD also affects other proteins and cell types in the brain, suggesting that the tau-centric view on Aβ toxicity should be revised.
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