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The phosphorylation cascade hypothesis of Alzheimer’s disease

Brinkmalm, G; Zetterberg, H; (2021) The phosphorylation cascade hypothesis of Alzheimer’s disease. Nature Aging , 1 (6) pp. 498-499. 10.1038/s43587-021-00077-9. Green open access

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Abstract

Alzheimer’s disease (AD) is characterized by amyloid-β (Aβ)-induced phosphorylation of the axon-stabilizing tau protein, which causes neurodegeneration. Here, Morshed et al. show that deregulated phosphorylation in AD also affects other proteins and cell types in the brain, suggesting that the tau-centric view on Aβ toxicity should be revised.

Type: Article
Title: The phosphorylation cascade hypothesis of Alzheimer’s disease
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s43587-021-00077-9
Publisher version: http://dx.doi.org/10.1038/s43587-021-00077-9
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10131989
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