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Retinal Changes in Transgenic Mouse Models of Alzheimer's Disease.

Guo, L; Ravindran, N; Shamsher, E; Hill, D; Cordeiro, MF; (2021) Retinal Changes in Transgenic Mouse Models of Alzheimer's Disease. Current Alzheimer Research , 18 (2) pp. 89-102. 10.2174/1567205018666210414113634. Green open access

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Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder, the most common form of dementia. AD is characterised by amyloid-β (Aβ) plaques and neurofibrillary tangles (NFT) in the brain, in association with neuronal loss and synaptic failure, causing cognitive deficits. Accurate and early diagnosis is currently unavailable in lifespan, hampering early intervention of potential new treatments. Visual deficits have been well documented in AD patients, and the pathological changes identified in the brain are also believed to be found in the retina, an integral part of the central nervous system. Retinal changes can be detected by real-time non-invasive imaging, due to the transparent nature of the ocular media, potentially allowing an earlier diagnosis as well as monitoring disease progression and treatment outcome. Animal models are essential for AD research, and this review has a focus on retinal changes in various transgenic AD mouse models with retinal imaging and immunohistochemical analysis as well as therapeutic effects in those models. We also discuss the limitations of transgenic AD models in clinical translations.

Type: Article
Title: Retinal Changes in Transgenic Mouse Models of Alzheimer's Disease.
Location: United Arab Emirates
Open access status: An open access version is available from UCL Discovery
DOI: 10.2174/1567205018666210414113634
Publisher version: http://doi.org/10.2174/1567205018666210414113634
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Alzheimer's disease, histology, in vivo imaging, retina, transgenic mouse models, treatment
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10131807
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