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A Versatile Hermetically Sealed Microelectronic Implant for Peripheral Nerve Stimulation Applications

Jiang, D; Liu, F; Lancashire, HT; Perkins, TA; Schormans, M; Vanhoestenberghe, A; Donaldson, NDN; (2021) A Versatile Hermetically Sealed Microelectronic Implant for Peripheral Nerve Stimulation Applications. Frontiers in Neuroscience , 15 , Article 681021. 10.3389/fnins.2021.681021. Green open access

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Abstract

This article presents a versatile neurostimulation platform featuring a fully implantable multi-channel neural stimulator for chronic experimental studies with freely moving large animal models involving peripheral nerves. The implant is hermetically sealed in a ceramic enclosure and encapsulated in medical grade silicone rubber, and then underwent active tests at accelerated aging conditions at 100°C for 15 consecutive days. The stimulator microelectronics are implemented in a 0.6-μm CMOS technology, with a crosstalk reduction scheme to minimize cross-channel interference, and high-speed power and data telemetry for battery-less operation. A wearable transmitter equipped with a Bluetooth Low Energy radio link, and a custom graphical user interface provide real-time, remotely controlled stimulation. Three parallel stimulators provide independent stimulation on three channels, where each stimulator supports six stimulating sites and two return sites through multiplexing, hence the implant can facilitate stimulation at up to 36 different electrode pairs. The design of the electronics, method of hermetic packaging and electrical performance as well as in vitro testing with electrodes in saline are presented.

Type: Article
Title: A Versatile Hermetically Sealed Microelectronic Implant for Peripheral Nerve Stimulation Applications
Open access status: An open access version is available from UCL Discovery
DOI: 10.3389/fnins.2021.681021
Publisher version: https://doi.org/10.3389/fnins.2021.681021
Language: English
Additional information: Copyright © 2021 Jiang, Liu, Lancashire, Perkins, Schormans, Vanhoestenberghe, Donaldson and Demosthenous. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Keywords: hermetic seal package, implantable stimulator, microelectronics, power and data telemetry, wireless stimulation control
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Electronic and Electrical Eng
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10131783
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