Kohnke, S;
Buller, S;
Nuzzaci, D;
Ridley, K;
Lam, B;
Pivonkova, H;
Bentsen, MA;
... Blouet, C; + view all
(2021)
Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence.
Cell Reports
, 36
(2)
, Article 109362. 10.1016/j.celrep.2021.109362.
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Abstract
The mediobasal hypothalamus (MBH; arcuate nucleus of the hypothalamus [ARH] and median eminence [ME]) is a key nutrient sensing site for the production of the complex homeostatic feedback responses required for the maintenance of energy balance. Here, we show that refeeding after an overnight fast rapidly triggers proliferation and differentiation of oligodendrocyte progenitors, leading to the production of new oligodendrocytes in the ME specifically. During this nutritional paradigm, ME perineuronal nets (PNNs), emerging regulators of ARH metabolic functions, are rapidly remodeled, and this process requires myelin regulatory factor (Myrf) in oligodendrocyte progenitors. In genetically obese ob/ob mice, nutritional regulations of ME oligodendrocyte differentiation and PNN remodeling are blunted, and enzymatic digestion of local PNN increases food intake and weight gain. We conclude that MBH PNNs are required for the maintenance of energy balance in lean mice and are remodeled in the adult ME by the nutritional control of oligodendrocyte differentiation.
| Type: | Article |
|---|---|
| Title: | Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.celrep.2021.109362 |
| Publisher version: | https://doi.org/10.1016/j.celrep.2021.109362 |
| Language: | English |
| Additional information: | © 2021 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Hypothalamus, energy balance, oligodendrocyte, median eminence, plasticity, nutrition, obesity, glucose homeostasis, perineuronal nets |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10131725 |
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