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Recurrent Urinary Tract Infection: A Mystery in Search of Better Model Systems

Murray, BO; Flores, C; Williams, C; Flusberg, DA; Marr, EE; Kwiatkowska, KM; Charest, JL; ... Rohn, JL; + view all (2021) Recurrent Urinary Tract Infection: A Mystery in Search of Better Model Systems. Frontiers in Cellular and Infection Microbiology , 11 , Article ARTN 691. 10.3389/fcimb.2021.691210. Green open access

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Abstract

Urinary tract infections (UTIs) are among the most common infectious diseases worldwide but are significantly understudied. Uropathogenic E. coli (UPEC) accounts for a significant proportion of UTI, but a large number of other species can infect the urinary tract, each of which will have unique host-pathogen interactions with the bladder environment. Given the substantial economic burden of UTI and its increasing antibiotic resistance, there is an urgent need to better understand UTI pathophysiology – especially its tendency to relapse and recur. Most models developed to date use murine infection; few human-relevant models exist. Of these, the majority of in vitro UTI models have utilized cells in static culture, but UTI needs to be studied in the context of the unique aspects of the bladder’s biophysical environment (e.g., tissue architecture, urine, fluid flow, and stretch). In this review, we summarize the complexities of recurrent UTI, critically assess current infection models and discuss potential improvements. More advanced human cell-based in vitro models have the potential to enable a better understanding of the etiology of UTI disease and to provide a complementary platform alongside animals for drug screening and the search for better treatments.

Type: Article
Title: Recurrent Urinary Tract Infection: A Mystery in Search of Better Model Systems
Open access status: An open access version is available from UCL Discovery
DOI: 10.3389/fcimb.2021.691210
Publisher version: https://doi.org/10.3389/fcimb.2021.691210
Language: English
Additional information: © 2021 Murray, Flores, Williams, Flusberg, Marr, Kwiatkowska, Charest, Isenberg and Rohn. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Keywords: urinary tract infection (UTI), microphysiological systems, in vitro infection model systems, organ-on-chip, organoid, urothelium, uropathogenic E. coli (UPEC), mouse models
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Renal Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10131714
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