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Peri-implantitis, systemic inflammation, and dyslipidemia: a cross-sectional biochemical study

Blanco, C; Liñares, A; Dopico, J; Pico, A; Sobrino, T; Leira, Y; Blanco, J; (2021) Peri-implantitis, systemic inflammation, and dyslipidemia: a cross-sectional biochemical study. Journal of Periodontal and Implant Science , 51 , Article e20. 10.5051/JPIS.2100920046. Green open access

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Abstract

Purpose: The aim of this study was to compare the inflammatory and lipid profile of patients with and without peri-implantitis. / Methods: A cross-sectional biochemical study was carried out in which blood samples were collected from 16 patients with peri-implantitis and from 31 subjects with healthy implants. Clinical peri-implant parameters were obtained from all subjects. Levels of tumor necrosis factor-alpha and interleukin-10 (IL-10) were measured in serum. Lipid fractions, glucose and creatinine levels, and complete blood count were also assessed. / Results: After controlling for a history of periodontitis, statistically significant differences between peri-implantitis patients and controls were found for total cholesterol (estimated adjusted mean difference, 76.4 mg/dL; 95% confidence interval [CI], 39.6, 113.2 mg/dL; P<0.001), low-density lipoprotein (LDL) cholesterol (estimated adjusted mean difference, 57.7 mg/dL; 95% CI, 23.8, 91.6 mg/dL; P<0.001), white blood cells (WBC) (estimated adjusted mean difference, 2.8×103/μL; 95% CI, 1.6, 4.0×103/μL; P<0.001) and IL-10 (estimated adjusted mean difference, −10.4 pg/mL; 95% CI, −15.8, −5.0 pg/mL; P<0.001). The peri- implant probing pocket depth (PPD) was modestly positively correlated with total cholesterol (r=0.512; P<0.001), LDL cholesterol (r=0.463; P=0.001), and WBC (r=0.519; P<0.001). A moderate negative correlation was observed between IL-10 and PPD (r=0.609; P<0.001). / Cardiovascular diseases; Dyslipidemias; Peri-implantitis; Inflammation; Leukocytes Conclusions: Otherwise healthy individuals with peri-implantitis showed increased low- grade systemic inflammation and dyslipidemia.

Type: Article
Title: Peri-implantitis, systemic inflammation, and dyslipidemia: a cross-sectional biochemical study
Open access status: An open access version is available from UCL Discovery
DOI: 10.5051/JPIS.2100920046
Publisher version: https://doi.org/10.5051/JPIS.2100920046
Language: English
Additional information: This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/).
Keywords: Cardiovascular diseases; Dyslipidemias; Peri-implantitis; Inflammation; Leukocytes
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Restorative Dental Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/10131643
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