Thornton, A;
Fraioli, F;
Wan, S;
Garthwaite, HS;
Ganeshan, B;
Shortman, RI;
Endozo, R;
... Groves, AM; + view all
(2021)
Evolution of 18F-FDG-PET/CT findings in patients following COVID-19 pneumonia: An Initial Investigation.
Journal of Nuclear Medicine
10.2967/jnumed.121.262296.
(In press).
Preview |
Text
jnumed.121.262296.full.pdf - Accepted Version Download (5MB) | Preview |
Abstract
Background: The evolution of pulmonary 18F-FDG uptake is unknown in patients with pneumonia due to SARS-CoV-2 (COVID-19 pneumonia) and in those with persistent respiratory symptoms post-COVID-19 termed Post-COVID-19 Lung-Disease (PCLD). The aim of this study was to assess the temporal evolution of pulmonary 18F-FDG uptake and identify a potential role for the use of 18F-FDG-PET/CT imaging in the management of these patients. Methods: Clinical data and CT imaging of all patients that underwent 18F-FDG-PET/CT imaging at UCLH, Lon-don during the UK pandemic were reviewed to find evidence of active or recovered SARS-CoV-2 infection. Results of PCR tests were used where available. Patients were divided in to acute (early and late) COVID-19 pneumonia, PCLD and asymptomatic recovery. 18F-FDG uptake in the lungs was measured as a target-to-background ratio (SUVmax/SUVmin) TBRlung which was compared to temporal-stage and plasma CRP. Results: There were 50 patients in total (median 61y, range 18-87y, 32-male): 23 incidental acute COVID-19 pneumonia cases identified retrospectively (8 Early, 15 Late), 9 asymptomatic recovered patients, and 18 cases performed for PCLD. In acute COVID-19 patients <3 weeks since disease onset TBRlung was strongly correlated with time since disease onset (rs=0.81, p<0.001).
| Type: | Article |
|---|---|
| Title: | Evolution of 18F-FDG-PET/CT findings in patients following COVID-19 pneumonia: An Initial Investigation |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.2967/jnumed.121.262296 |
| Publisher version: | https://doi.org/10.2967/jnumed.121.262296 |
| Language: | English |
| Additional information: | Copyright © 2021 by the Society of Nuclear Medicine and Molecular Imaging, Inc. Available under the Creative Commons Attribution 4.0 International License (CC BY) that allows users to share and adapt with attribution, excluding materials credited to previous publications. |
| Keywords: | 18F-FDG, COVID-19, Infectious Disease, PET/CT, Respiratory |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10131541 |
Archive Staff Only
 |
View Item |
