Coneys, R;
Storm, CS;
Kia, DA;
Almramhi, M;
Wood, NW;
(2021)
Mendelian Randomisation Finds No Causal Association between Urate and Parkinson's Disease Progression.
Movement Disorders
10.1002/mds.28662.
(In press).
Text
mds.28662.pdf - Accepted Version Access restricted to UCL open access staff Download (296kB) |
Abstract
BACKGROUND: Parkinson's disease (PD) is a common neurodegenerative movement disorder. Observational studies suggest higher levels of plasma urate may protect against Parkinson's risk and progression; however, causality cannot be established. OBJECTIVES: This study set out to determine whether there is a true causal association between urate levels and PD age at onset (AAO) and progression severity using recently released PD AAO and progression genome-wide association study (GWAS) data. METHODS: A large two-sample Mendelian randomization design was employed, using genetic variants underlying urate levels and the latest GWAS data for PD outcomes. RESULTS: This study found no causal association between urate levels and Parkinson's risk, AAO, or progression severity. CONCLUSIONS: Our results predict increasing urate levels as a therapeutic strategy is unlikely to benefit PD patients. © 2021 International Parkinson and Movement Disorder Society
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