UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Optimization and assessment of a novel gastric electrode anchoring system designed to be implanted by minimally invasive surgery

Debelle, A; de Rooster, H; Bianchini, E; Lonys, L; Huberland, F; Vanhoestenberghe, A; Lambert, P; ... Nonclercq, A; + view all (2021) Optimization and assessment of a novel gastric electrode anchoring system designed to be implanted by minimally invasive surgery. Medical Engineering & Physics , 92 pp. 93-101. 10.1016/j.medengphy.2021.05.004. Green open access

[thumbnail of Vanhoestenberghe_Debelle et al 2021_accepted_CClicensed.pdf]
Preview
Text
Vanhoestenberghe_Debelle et al 2021_accepted_CClicensed.pdf - Accepted Version

Download (1MB) | Preview

Abstract

A novel electrode anchoring design and its implantation procedure, aiming for a minimally invasive solution for gastric electrical stimulation, are presented. The system comprises an anchor made of a flexible body embedding two needle-shaped electrodes. The electrodes can easily switch from a parallel position – to pierce the stomach – to a diverging position – enabling them to remain firmly anchored into the muscular layer of the stomach. Key device parameters governing anchoring stability were assessed on a traction test bench, and optimal values were derived. The device was then implanted in six dogs by open surgery to assess its anchoring durability in vivo. Computed tomography images showed that the electrodes remained well placed within the dogs’ gastric wall over the entire assessment period (more than one year). Finally, a prototype of a surgical tool for the minimally invasive device placement was manufactured, and the anchoring procedure was tested on a dog cadaver, providing the proof of concept of the minimally invasive implantation procedure. The use of our electrode anchoring system in long-term gastric electrical stimulation is promising in terms of implantation stability (the anchor withstands a force up to 0.81 N), durability (the anchor remains onto the stomach over one year) and minimal invasiveness of the procedure (the diameter of the percutaneous access is smaller than 12 mm). Moreover, the proposed design could have clinical applications in other hollow organs, such as the urinary bladder.

Type: Article
Title: Optimization and assessment of a novel gastric electrode anchoring system designed to be implanted by minimally invasive surgery
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.medengphy.2021.05.004
Publisher version: http://dx.doi.org/10.1016/j.medengphy.2021.05.004
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Electrode anchoring, Percutaneous implantation, Single incision surgery, In-vivo validation, Gastric electrical stimulation, REDUCES FOOD-INTAKE, MEDICAL-CARE COSTS, ELECTRICAL-STIMULATION, MORBID-OBESITY, DYSFUNCTION, MECHANISMS, RECOVERY, BOWEL
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science
URI: https://discovery.ucl.ac.uk/id/eprint/10131204
Downloads since deposit
98Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item