UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Dynamics of Transforming Growth Factor (TGF)-beta Superfamily Cytokine Induction During HIV-1 Infection Are Distinct From Other Innate Cytokines

Dickinson, M; Kliszczak, AE; Giannoulatou, E; Peppa, D; Pellegrino, P; Williams, I; Drakesmith, H; (2020) Dynamics of Transforming Growth Factor (TGF)-beta Superfamily Cytokine Induction During HIV-1 Infection Are Distinct From Other Innate Cytokines. Frontiers in Immunology , 11 , Article 596841. 10.3389/fimmu.2020.596841. Green open access

[thumbnail of fimmu-11-596841.pdf]
Preview
Text
fimmu-11-596841.pdf - Published Version

Download (1MB) | Preview

Abstract

Human immunodeficiency virus type 1 (HIV-1) infection triggers rapid induction of multiple innate cytokines including type I interferons, which play important roles in viral control and disease pathogenesis. The transforming growth factor (TGF)-β superfamily is a pleiotropic innate cytokine family, some members of which (activins and bone morphogenetic proteins (BMPs)) were recently demonstrated to exert antiviral activity against Zika and hepatitis B and C viruses but are poorly studied in HIV-1 infection. Here, we show that TGF-β1 is systemically induced with very rapid kinetics (as early as 1–4 days after viremic spread begins) in acute HIV-1 infection, likely due to release from platelets, and remains upregulated throughout infection. Contrastingly, no substantial systemic upregulation of activins A and B or BMP-2 was observed during acute infection, although plasma activin levels trended to be elevated during chronic infection. HIV-1 triggered production of type I interferons but not TGF-β superfamily cytokines from plasmacytoid dendritic cells (DCs) in vitro, putatively explaining their differing in vivo induction; whilst lipopolysaccharide (but not HIV-1) elicited activin A production from myeloid DCs. These findings underscore the need for better definition of the protective and pathogenic capacity of TGF-β superfamily cytokines, to enable appropriate modulation for therapeutic purposes.

Type: Article
Title: Dynamics of Transforming Growth Factor (TGF)-beta Superfamily Cytokine Induction During HIV-1 Infection Are Distinct From Other Innate Cytokines
Open access status: An open access version is available from UCL Discovery
DOI: 10.3389/fimmu.2020.596841
Publisher version: https://doi.org/10.3389/fimmu.2020.596841
Language: English
Additional information: © 2020 Dickinson, Kliszczak, Giannoulatou, Peppa, Pellegrino, Williams, Drakesmith and Borrow. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/).
Keywords: HIV, TGF-beta, activin, interferon, cytokine, dendritic cell, innate response, bone morphogenetic protein
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health
URI: https://discovery.ucl.ac.uk/id/eprint/10131133
Downloads since deposit
12Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item