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Impaired neural replay of inferred relationships in schizophrenia.

Nour, MM; Liu, Y; Arumuham, A; Kurth-Nelson, Z; Dolan, RJ; (2021) Impaired neural replay of inferred relationships in schizophrenia. Cell 10.1016/j.cell.2021.06.012. (In press). Green open access

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Abstract

An ability to build structured mental maps of the world underpins our capacity to imagine relationships between objects that extend beyond experience. In rodents, such representations are supported by sequential place cell reactivations during rest, known as replay. Schizophrenia is proposed to reflect a compromise in structured mental representations, with animal models reporting abnormalities in hippocampal replay and associated ripple activity during rest. Here, utilizing magnetoencephalography (MEG), we tasked patients with schizophrenia and control participants to infer unobserved relationships between objects by reorganizing visual experiences containing these objects. During a post-task rest session, controls exhibited fast spontaneous neural reactivation of presented objects that replayed inferred relationships. Replay was coincident with increased ripple power in hippocampus. Patients showed both reduced replay and augmented ripple power relative to controls, convergent with findings in animal models. These abnormalities are linked to impairments in behavioral acquisition and subsequent neural representation of task structure.

Type: Article
Title: Impaired neural replay of inferred relationships in schizophrenia.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.cell.2021.06.012
Publisher version: https://doi.org/10.1016/j.cell.2021.06.012
Language: English
Additional information: © 2021 The Author(s). Published by Elsevier Inc. 1 This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Cognitive map, mental simulation, model-based inference, psychosis, schema
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/10131116
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