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Cardiac Amyloidosis Multimodal Imaging of Disease Activity and Response to Treatment

Patel, RK; Fontana, M; Ruberg, FL; (2021) Cardiac Amyloidosis Multimodal Imaging of Disease Activity and Response to Treatment. Circulation: Cardiovascular Imaging , 14 (6) , Article e009025. 10.1161/CIRCIMAGING.121.009025. Green open access

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Abstract

Cardiac amyloidosis (CA) is a disease characterized by the deposition of misfolded protein deposits in the myocardial interstitium. Although advanced CA confers significant morbidity and mortality, the magnitude of deposition and ensuing clinical manifestations vary greatly. Thus, an improved understanding of disease pathogenesis at both cellular and functional levels would afford critical insights that may improve outcomes. This review will summarize contemporary therapies for the 2 major types of CA, transthyretin and light chain amyloidosis, and outline the capacity of imaging modalities to both diagnose CA, inform prognosis, and follow response to available therapies. We explore the current landscape of echocardiography, cardiac magnetic resonance, and bone scintigraphy in the assessment of functional and cellular parameters of dysfunction in CA throughout disease pathogenesis. Finally, we examine the impact of concurrent advances in both therapeutics and imaging on future research questions that improve our understanding of underlying disease mechanisms. Multimodal imaging in CA affords an indispensable tool to offer individualized treatment plans and improve outcomes in patients with CA.

Type: Article
Title: Cardiac Amyloidosis Multimodal Imaging of Disease Activity and Response to Treatment
Open access status: An open access version is available from UCL Discovery
DOI: 10.1161/CIRCIMAGING.121.009025
Publisher version: https://doi.org/10.1161/CIRCIMAGING.121.009025
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10131060
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