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Potential Use of Shared Frameshift Mutations in 'Off-the-Shelf' Neoantigen Vaccines

Thol, K; McGranahan, N; (2021) Potential Use of Shared Frameshift Mutations in 'Off-the-Shelf' Neoantigen Vaccines. Trends in Cancer , 7 (3) pp. 175-177. 10.1016/j.trecan.2021.01.002. Green open access

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Abstract

Neoantigens derived from frameshift mutations in microsatellite unstable tumours are more commonly shared between different patients' cancers compared with neoantigens arising from missense mutations. A recent study by Roudko et al. evaluates the immunogenicity of shared frameshift neoantigens, which could potentially be used in ‘off-the-shelf’ neoantigen vaccines.

Type: Article
Title: Potential Use of Shared Frameshift Mutations in 'Off-the-Shelf' Neoantigen Vaccines
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.trecan.2021.01.002
Publisher version: https://doi.org/10.1016/j.trecan.2021.01.002
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: https://discovery.ucl.ac.uk/id/eprint/10130986
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