Abolaban, FA;
Banoqitah, EM;
Taha, EM;
Alhawsawi, AM;
Djouider, FA;
Nisbet, A;
(2021)
Production of actinium-225 from a (n,p) reaction: Feasibility and pre-design studies.
Nukleonika
, 66
(2)
pp. 61-67.
10.2478/nuka-2021-0008.
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Abstract
Actinium-225 is used in nuclear medicine for the treatment of malignant tumours. It can be applied to produce Bi-213 in a reusable generator or can be used alone as an agent for radiation therapy, in particular for targeted alpha therapy. However, the availability of Ac-225 for worldwide use, particularly in low- and middle-income countries, is limited. We present a feasibility study employing GATE, an open-source Monte Carlo simulation toolkit, on the production of Ac-225 from a neutron generator. This work suggests that a design consisting of three concentric cylinders, the innermost a Cf-252 neutron source, the middle nickel cylinder acting as a proton-producing target and the outer cylinder a RaCl2 target may provide a feasible design outline for an Ac-225 generator.
| Type: | Article |
|---|---|
| Title: | Production of actinium-225 from a (n,p) reaction: Feasibility and pre-design studies |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.2478/nuka-2021-0008 |
| Publisher version: | https://doi.org/10.2478/nuka-2021-0008 |
| Language: | English |
| Additional information: | © 2021 The Author(s). Published by the Institute of Nuclear Chemistry and Technology. This is an open access article under the CC BY-NC-ND 4.0 licence (http://creativecommons.org/licences/by-nc-nd/4.0/) |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10130932 |
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