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The Role of Capsid in the Early Steps of HIV-1 Infection: New Insights into the Core of the Matter

AlBurtamani, N; Paul, A; Fassati, A; (2021) The Role of Capsid in the Early Steps of HIV-1 Infection: New Insights into the Core of the Matter. Viruses , 13 (6) , Article 1161. 10.3390/v13061161. Green open access

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Abstract

In recent years, major advances in research and experimental approaches have significantly increased our knowledge on the role of the HIV-1 capsid in the virus life cycle, from reverse transcription to integration and gene expression. This makes the capsid protein a good pharmacological target to inhibit HIV-1 replication. This review covers our current understanding of the role of the viral capsid in the HIV-1 life cycle and its interaction with different host factors that enable reverse transcription, trafficking towards the nucleus, nuclear import and integration into host chromosomes. It also describes different promising small molecules, some of them in clinical trials, as potential targets for HIV-1 therapy.

Type: Article
Title: The Role of Capsid in the Early Steps of HIV-1 Infection: New Insights into the Core of the Matter
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.3390/v13061161
Publisher version: https://doi.org/10.3390/v13061161
Language: English
Additional information: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
Keywords: HIV-1, capsid, drugs, integration, nuclear entry, reverse transcription
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
URI: https://discovery.ucl.ac.uk/id/eprint/10130838
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