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Organ transplantation from deceased donors with vaccine-induced thrombosis and thrombocytopenia

Greenhall, GHB; Ushiro-Lumb, I; Pavord, S; Currie, I; Perera, MTPR; Hartog, H; Hill, QA; ... UK Donor VITT Transplant Study Group; + view all (2021) Organ transplantation from deceased donors with vaccine-induced thrombosis and thrombocytopenia. American Journal of Transplantation 10.1111/ajt.16735. (In press). Green open access

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Abstract

Vaccine-induced thrombosis and thrombocytopenia (VITT) may follow immunisation with the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2. Autoantibodies to platelet factor 4 (PF4) may mediate VITT through antibody-dependent platelet activation, though the underlying etiology is uncertain. Anti-PF4 antibodies are also seen in heparin-induced thrombocytopenia, though most cases of VITT do not have prior heparin exposure. More than 20 million people in the United Kingdom (UK) have received the ChAdOx1 nCoV-19 vaccine.

Type: Article
Title: Organ transplantation from deceased donors with vaccine-induced thrombosis and thrombocytopenia
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/ajt.16735
Publisher version: http://dx.doi.org/10.1111/ajt.16735
Language: English
Additional information: This article is protected by copyright. All rights reserved. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/10130681
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