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ATR based infrared spectroscopy for the diagnosis of neonatal respiratory distress syndrome

Ahmed, W; Veluthandath, AV; Madsen, J; Clark, HW; Postle, AD; Wilkinson, JS; Murugan, GS; (2021) ATR based infrared spectroscopy for the diagnosis of neonatal respiratory distress syndrome. In: Proceedings of Optical Diagnostics and Sensing XXI: Toward Point-of-Care Diagnostics. (pp. p. 1165104). SPIE: Online Only. Green open access

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Abstract

Optical spectroscopy offers a potential non-invasive, label free and rapid method to assist clinicians to diagnose diseases for which biomarkers are known. Neonatal respiratory distress syndrome (nRDS) diagnosis in preterm infants is known to be correlated with the lecithin/sphingomyelin ratio (LS ratio) in gastric aspirates, with a ratio less than 2.2 indicating that surfactant replacement therapy is needed. Currently no widespread method exists that can give clinically relevant answers in less than 2 hours from the point of sample collection as it is difficult to identify those who could benefit from prompt surfactant treatment. Various LS ratios were generated using pure dipalmitoylphosphatidylcholine (DPPC) and sphingomyelin (SM) dissolved in dichloromethane and infrared spectra generated using Attenuated Total Reflection (ATR) assisted Fourier Transform InfraRed spectrometry (FTIR). Subsequent analysis obtained the LS ratio using the spectra alone. Further, we demonstrate the application of principal component regression (PCR) and partial least squares (PLS) fits to measured spectra to assist in the determination of the LS ratio using a model trained with multiple runs of the different batches of the same concentration.

Type: Proceedings paper
Title: ATR based infrared spectroscopy for the diagnosis of neonatal respiratory distress syndrome
Event: SPIE BiOS
ISBN-13: 9781510641372
Open access status: An open access version is available from UCL Discovery
DOI: 10.1117/12.2578818
Publisher version: https://doi.org/10.1117/12.2578818
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Neonatology
URI: https://discovery.ucl.ac.uk/id/eprint/10130480
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