Gunzinger, J;
Moore, P;
Athimalaipet, R;
Dick, A;
(2021)
Adalimumab in the treatment of pediatric patients with chronic noninfectious anterior uveitis.
Expert Review of Ophthalmology
, 16
(4)
pp. 231-241.
10.1080/17469899.2021.1935240.
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Abstract
Introduction: Adalimumab is established as an effective treatment for pediatric noninfectious uveitis refractory to methotrexate. However current use of the medication is empiric, according to fixed-dosing regimens and a significant proportion of patients will be nonresponsive or suboptimally responsive to adalimumab. Areas covered: There remains considerable scope to improve outcomes through tailoring treatment according to individual patient responsiveness. Monitoring of anti-drug antibodies and serum drug trough levels may assist in predicting which patients are likely to have a poor response to adalimumab and enable tailoring of regimens to individual patients. Expert opinion: We propose use of these biomarkers to individualize therapy in suboptimally responding patients, and present an algorithm of treatment escalation for pediatric noninfectious uveitis.
| Type: | Article |
|---|---|
| Title: | Adalimumab in the treatment of pediatric patients with chronic noninfectious anterior uveitis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1080/17469899.2021.1935240 |
| Publisher version: | https://doi.org/10.1080/17469899.2021.1935240 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| Keywords: | Adalimumab, noninfectious pediatric uveitis, pediatric uveitis, anti-drug antibodies, uveitis treatment, adalimumab monitoring |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10130396 |
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