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Adalimumab in the treatment of pediatric patients with chronic noninfectious anterior uveitis

Gunzinger, J; Moore, P; Athimalaipet, R; Dick, A; (2021) Adalimumab in the treatment of pediatric patients with chronic noninfectious anterior uveitis. Expert Review of Ophthalmology , 16 (4) pp. 231-241. 10.1080/17469899.2021.1935240. Green open access

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Abstract

Introduction: Adalimumab is established as an effective treatment for pediatric noninfectious uveitis refractory to methotrexate. However current use of the medication is empiric, according to fixed-dosing regimens and a significant proportion of patients will be nonresponsive or suboptimally responsive to adalimumab. Areas covered: There remains considerable scope to improve outcomes through tailoring treatment according to individual patient responsiveness. Monitoring of anti-drug antibodies and serum drug trough levels may assist in predicting which patients are likely to have a poor response to adalimumab and enable tailoring of regimens to individual patients. Expert opinion: We propose use of these biomarkers to individualize therapy in suboptimally responding patients, and present an algorithm of treatment escalation for pediatric noninfectious uveitis.

Type: Article
Title: Adalimumab in the treatment of pediatric patients with chronic noninfectious anterior uveitis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/17469899.2021.1935240
Publisher version: https://doi.org/10.1080/17469899.2021.1935240
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: Adalimumab, noninfectious pediatric uveitis, pediatric uveitis, anti-drug antibodies, uveitis treatment, adalimumab monitoring
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10130396
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