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PCV13 induced IgG responses in serum associate with serotype-specific IgG in the lung

Mitsi, E; McLenaghan, D; Wolf, AS; Jones, S; Collins, AM; Hyder-Wright, A; Goldblatt, D; ... Ferreira, DM; + view all (2021) PCV13 induced IgG responses in serum associate with serotype-specific IgG in the lung. The Journal of Infectious Diseases 10.1093/infdis/jiab331. (In press). Green open access

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Abstract

Pneumococcal conjugate vaccine efficacy is lower for non-invasive pneumonia than invasive disease. In this study, participants were vaccinated with PCV13 or HepA (control). Bronchoalveolar lavage samples were taken between 2-6 months and serum at 4- and 7-weeks post vaccination. In the lung, anti-capsular IgG levels were higher in the PCV13 group compared to control for all serotypes, except 3 and 6B. Systemically, IgG levels were elevated in the PCV group at 4-weeks for all serotypes, except 3. IgG in BAL and serum positively correlated for nearly all serotypes. PCV13 shows poor immunogenicity to serotype 3, implying lack of protective efficacy. Clinical trial registration with ISRCTN: 45340436

Type: Article
Title: PCV13 induced IgG responses in serum associate with serotype-specific IgG in the lung
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/infdis/jiab331
Publisher version: https://doi.org/10.1093/infdis/jiab331
Language: English
Additional information: Copyright © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: BAL, PCV13, Pneumococcus, anti-capsular IgG
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10130359
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