Paci, G;
Mao, Y;
(2021)
Forced into shape: Mechanical forces in Drosophila development and homeostasis.
Seminars in Cell & Developmental Biology
10.1016/j.semcdb.2021.05.026.
(In press).
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Abstract
Mechanical forces play a central role in shaping tissues during development and maintaining epithelial integrity in homeostasis. In this review, we discuss the roles of mechanical forces in Drosophila development and homeostasis, starting from the interplay of mechanics with cell growth and division. We then discuss several examples of morphogenetic processes where complex 3D structures are shaped by mechanical forces, followed by a closer look at patterning processes. We also review the role of forces in homeostatic processes, including cell elimination and wound healing. Finally, we look at the interplay of mechanics and developmental robustness and discuss open questions in the field, as well as novel approaches that will help tackle them in the future.
| Type: | Article |
|---|---|
| Title: | Forced into shape: Mechanical forces in Drosophila development and homeostasis |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.semcdb.2021.05.026 |
| Publisher version: | http://dx.doi.org/10.1016/j.semcdb.2021.05.026 |
| Language: | English |
| Additional information: | © 2021 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) |
| Keywords: | Drosophila development, Homeostasis, Mechanical forces, Morphogenesis, Patterning |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10130114 |
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