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How do participants in clinical trials compare with other patients with schizophrenia?

Freudenthal, R; Marston, L; Stansfeld, JL; Priebe, S; Moncrieff, J; (2021) How do participants in clinical trials compare with other patients with schizophrenia? Contemporary Clinical Trials Communications , 22 , Article 100803. 10.1016/j.conctc.2021.100803. Green open access

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Abstract

We aimed to explore the clinical relevance of a multicentre, pragmatic randomised trial of antipsychotic reduction in people diagnosed with schizophrenia or psychosis The sample recruited for the antipsychotic reduction study (n = 69 people) was compared with the population of patients with an eligible diagnosis undergoing treatment in the same service (n = 3067 people), using routinely-collected, anonymised data. The trial sample was found to resemble the wider population in terms of the number of past admissions, the likelihood of having been subject to legal detention and the level of risk the patient was perceived to pose to themselves or others. There was a lower proportion of people from minority ethnic backgrounds in the trial sample. The results provide some reassurance that trial recruits were similar to the wider population in terms of the severity of their condition and did not comprise a highly select sample of people with milder problems. The different ethnic composition of the research sample is consistent with other research.

Type: Article
Title: How do participants in clinical trials compare with other patients with schizophrenia?
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.conctc.2021.100803
Publisher version: http://dx.doi.org/10.1016/j.conctc.2021.100803
Language: English
Additional information: © 2021 Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Clinical trials, Psychosis, Schizophrenia, Antipsychotics
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Primary Care and Population Health
URI: https://discovery.ucl.ac.uk/id/eprint/10129980
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