UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Towards an extension of the two-variable model of carcinogenesis through oncogenes and tumour suppressor genes

Tourvas, A-D; Frangos, CC; (2011) Towards an extension of the two-variable model of carcinogenesis through oncogenes and tumour suppressor genes. Medical Hypotheses , 77 (6) pp. 956-958. 10.1016/j.mehy.2011.08.017. Green open access

[thumbnail of Final Submission_Tourvas and Fragkos_ucl.pdf]
Preview
Text
Final Submission_Tourvas and Fragkos_ucl.pdf - Accepted Version

Download (107kB) | Preview

Abstract

Currently, carcinogenesis is considered to be the result of mal-expression of tumour suppressor genes and oncogenes, leading either way to uncontrollable and disorganized cell mitosis. Recently a novel class of genes has drawn the interest of the scientific community. These are microRNAs (miRNAs), a class of noncoding RNAs, 20–23 nucleotides in length, that can up or downregulate gene expression of downstream gene targets (including transcription factors, oncogenes, and tumour suppressor genes) at the post-transcriptional level. Some members of this new class of genes seem to have the potential to act simultaneously either as oncogenes or as tumour suppressor genes depending on the molecular microenvironment of the cell. We elaborate on this hypothesis by giving examples of miRNAs (e.g. mir-9, miR-17-92) which seem to function by the abovementioned mechanism. This could mean that the deterministic notion of carcinogenesis as a result of merely tumour suppressor genes and oncogenes deregulation could be revised to contain the fact that certain members of this novel class of genes have the potential to play both roles simultaneously.

Type: Article
Title: Towards an extension of the two-variable model of carcinogenesis through oncogenes and tumour suppressor genes
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.mehy.2011.08.017
Publisher version: http://doi.org/10.1016/j.mehy.2011.08.017
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10129830
Downloads since deposit
7Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item