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Courier service for phosphatidylinositol: PITPs deliver on demand

Ashlin, TG; Blunsom, NJ; Cockcroft, S; (2021) Courier service for phosphatidylinositol: PITPs deliver on demand. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids , 1866 (9) , Article 158985. 10.1016/j.bbalip.2021.158985. Green open access

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Abstract

Phosphatidylinositol is the parent lipid for the synthesis of seven phosphorylated inositol lipids and each of them play specific roles in numerous processes including receptor-mediated signalling, actin cytoskeleton dynamics and membrane trafficking. PI synthesis is localised to the endoplasmic reticulum (ER) whilst its phosphorylated derivatives are found in other organelles where the lipid kinases also reside. Phosphorylation of PI to phosphatidylinositol (4,5) bisphosphate (PI(4,5)P_{2}) at the plasma membrane and to phosphatidylinositol 4-phosphate (PI4P) at the Golgi are key events in lipid signalling and Golgi function respectively. Here we review a family of proteins, phosphatidylinositol transfer proteins (PITPs), that can mobilise PI from the ER to provide the substrate to the resident kinases for phosphorylation. Recent studies identify specific and overlapping functions for the three soluble PITPs (PITPα, PITPβ and PITPNC1) in phospholipase C signalling, neuronal function, membrane trafficking, viral replication and in cancer metastases.

Type: Article
Title: Courier service for phosphatidylinositol: PITPs deliver on demand
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.bbalip.2021.158985
Publisher version: https://doi.org/10.1016/j.bbalip.2021.158985
Language: English
Additional information: © 2021 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Golgi, Lipid transfer, Membrane traffic, PITPNC1, Phosphatidic acid, Phosphatidylinositol, Phospholipase C
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: https://discovery.ucl.ac.uk/id/eprint/10129590
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