Deng, Y;
Chatterjee, B;
Zens, K;
Zdimerova, H;
Müller, A;
Schuhmachers, P;
Ligeon, L-A;
... Münz, C; + view all
(2021)
CD27 is required for protective lytic EBV antigen-specific CD8+ T-cell expansion.
Blood
, 137
(23)
pp. 3225-3236.
10.1182/blood.2020009482.
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BLD-2020-009482R1-A manuscript 250321.pdf - Accepted Version Download (32MB) | Preview |
Abstract
Primary immunodeficiencies in the costimulatory molecule CD27 and its ligand, CD70, predispose for pathologies of uncontrolled Epstein-Barr virus (EBV) infection in nearly all affected patients. We demonstrate that both depletion of CD27+ cells and antibody blocking of CD27 interaction with CD70 cause uncontrolled EBV infection in mice with reconstituted human immune system components. While overall CD8+ T-cell expansion and composition are unaltered after antibody blocking of CD27, only some EBV-specific CD8+ T-cell responses, exemplified by early lytic EBV antigen BMLF1-specific CD8+ T cells, are inhibited in their proliferation and killing of EBV-transformed B cells. This suggests that CD27 is not required for all CD8+ T-cell expansions and cytotoxicity but is required for a subset of CD8+ T-cell responses that protect us from EBV pathology.
| Type: | Article |
|---|---|
| Title: | CD27 is required for protective lytic EBV antigen-specific CD8+ T-cell expansion |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1182/blood.2020009482 |
| Publisher version: | http://dx.doi.org/10.1182/blood.2020009482 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | CD27, CD39, DLBCL, Epstein-Barr virus, IMMUNOBIOLOGY/B-cell neoplasms, IMMUNOBIOLOGY/Cytotoxic T cells, IMMUNOBIOLOGY/Host-pathogen interactions, IMMUNOBIOLOGY/T-Cell Mediated Immunity, IMMUNOBIOLOGY/T-cell costimulation, humanized mice |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10129568 |
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