Vogt, NM;
Hunt, JF;
Adluru, N;
Ma, Y;
Van Hulle, CA;
Dean, DC;
Kecskemeti, SR;
... Bendlin, BB; + view all
(2022)
Interaction of amyloid and tau on cortical microstructure in cognitively unimpaired adults.
Alzheimer's & Dementia
, 18
(1)
pp. 65-76.
10.1002/alz.12364.
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Abstract
INTRODUCTION: Neurite orientation dispersion and density imaging (NODDI), a multi-compartment diffusion-weighted imaging (DWI) model, may be useful for detecting early cortical microstructural alterations in Alzheimer's disease prior to cognitive impairment. METHODS: Using neuroimaging (NODDI and T1-weighted magnetic resonance imaging [MRI]) and cerebrospinal fluid (CSF) biomarker data (measured using Elecsys® CSF immunoassays) from 219 cognitively unimpaired participants, we tested the main and interactive effects of CSF amyloid beta (Aβ)42/Aβ40 and phosphorylated tau (p-tau) on cortical NODDI metrics and cortical thickness, controlling for age, sex, and apolipoprotein E ε4. RESULTS: We observed a significant CSF Aβ42/Aβ40 × p-tau interaction on cortical neurite density index (NDI), but not orientation dispersion index or cortical thickness. The directionality of these interactive effects indicated: (1) among individuals with lower CSF p-tau, greater amyloid burden was associated with higher cortical NDI; and (2) individuals with greater amyloid and p-tau burden had lower cortical NDI, consistent with cortical neurodegenerative changes. DISCUSSION: NDI is a particularly sensitive marker for early cortical changes that occur prior to gross atrophy or development of cognitive impairment.
| Type: | Article |
|---|---|
| Title: | Interaction of amyloid and tau on cortical microstructure in cognitively unimpaired adults |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/alz.12364 |
| Publisher version: | https://doi.org/10.1002/alz.12364 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Cortical microstructure, cerebrospinal fluid biomarkers, diffusion, magnetic resonance imaging,neurite orientation dispersion and density imaging, preclinical |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10129538 |
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