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Digital Twins for Bioprocess Control Strategy Development and Realisation

Appl, C; Moser, A; Baganz, F; Hass, VC; (2021) Digital Twins for Bioprocess Control Strategy Development and Realisation. Digital Twins , 177 pp. 63-94. 10.1007/10_2020_151. Green open access

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Abstract

New innovative Digital Twins can represent complex bioprocesses, including the biological, physico-chemical, and chemical reaction kinetics, as well as the mechanical and physical characteristics of the reactors and the involved peripherals. Digital Twins are an ideal tool for the rapid and cost-effective development, realisation and optimisation of control and automation strategies. They may be utilised for the development and implementation of conventional controllers (e.g. temperature, dissolved oxygen, etc.), as well as for advanced control strategies (e.g. control of substrate or metabolite concentrations, multivariable controls), and the development of complete bioprocess control. This chapter describes the requirements Digital Twins must fulfil to be used for bioprocess control strategy development, and implementation and gives an overview of research projects where Digital Twins or "early-stage" Digital Twins were used in this context. Furthermore, applications of Digital Twins for the academic education of future control and bioprocess engineers as well as for the training of future bioreactor operators will be described. Finally, a case study is presented, in which an "early-stage" Digital Twin was applied for the development of control strategies of the fed-batch cultivation of Saccharomyces cerevisiae. Development, realisation and optimisation of control strategies utilising Digital Twins.

Type: Article
Title: Digital Twins for Bioprocess Control Strategy Development and Realisation
Location: Germany
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/10_2020_151
Publisher version: https://doi.org/10.1007/10_2020_151
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: Bioprocess, Control strategy development, Digital Twin, Operator training simulator (OTS), Automation, Bioreactors, Oxygen, Saccharomyces cerevisiae
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10129531
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