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Recent advances in modelling and control of liquid chromatography

Besenhard, MO; Tsatse, A; Mazzei, L; Sorensen, E; (2021) Recent advances in modelling and control of liquid chromatography. Current Opinion in Chemical Engineering , 32 , Article 100685. 10.1016/j.coche.2021.100685. Green open access

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Abstract

For more than a century, chromatography has been indispensable as a separation method for both analytics and purification. Among the variety of chromatographic techniques, liquid chromatography has a special status owing to its efficiency and versatility, and its status is further enhanced by the continuous improvements of analysers, materials, methods and understanding, all supported by computational approaches. High performance liquid chromatography (HPLC) has always held a special place in pharmaceutical processing, and computational HPLC has been explored since the very early stages of computing, although without having yet reached its full potential. Herein, we provide a comprehensive and critical review of recent developments in designing and operating liquid chromatographic systems, focussing on their modelling approaches and control strategies at large scale.

Type: Article
Title: Recent advances in modelling and control of liquid chromatography
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.coche.2021.100685
Publisher version: https://doi.org/10.1016/j.coche.2021.100685
Language: English
Additional information: © 2021 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons. org/licenses/by/4.0/).
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Chemical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10129364
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