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Test-retest reliability of spatial navigation in adults at-risk of Alzheimer's disease

Coughlan, G; Puthusseryppady, V; Lowry, E; Gillings, R; Spiers, H; Minihane, A-M; Hornberger, M; (2020) Test-retest reliability of spatial navigation in adults at-risk of Alzheimer's disease. PLOS ONE , 15 (9) , Article e0239077. 10.1371/journal.pone.0239077. Green open access

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Abstract

The Virtual Supermarket Task (VST) and Sea Hero Quest detect high-genetic-risk Alzheimer`s disease (AD). We aimed to determine their test-retest reliability in a preclinical AD population. Over two time points, separated by an 18-month period, 59 cognitively healthy individuals underwent a neuropsychological and spatial navigation assessment. At baseline, participants were classified as low-genetic-risk of AD or high-genetic-risk of AD. We calculated two-way mixed effects intraclass correlation coefficients (ICC) for task parameters and used repeated measures ANOVAS to determine whether genetic risk or sex contributed to test-retest variability. The egocentric parameter of the VST measure showed the highest test–retest reliability (ICC = .72), followed by the SHQ distance travelled parameter (ICC = .50). Post hoc longitudinal analysis showed that boundary-based navigation predicts worsening episodic memory concerns in high-risk (F = 5.01, P = 0.03), but in not low-risk, AD candidates. The VST and the Sea Hero Quest produced parameters with acceptable test-retest reliability. Further research in larger sample sizes is desirable.

Type: Article
Title: Test-retest reliability of spatial navigation in adults at-risk of Alzheimer's disease
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0239077
Publisher version: https://doi.org/10.1371/journal.pone.0239077
Language: English
Additional information: Copyright © 2020 Coughlan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Alzheimer's disease, Memory, Neuropsychology, Neuropsychological testing, Genetics, Heredity, Cognitive impairment, Spatial memory
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Experimental Psychology
URI: https://discovery.ucl.ac.uk/id/eprint/10129337
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