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Similarities and Differences Between Juvenile and Adult Spondyloarthropathies

Fisher, C; Ciurtin, C; Leandro, M; Sen, D; Wedderburn, LR; (2021) Similarities and Differences Between Juvenile and Adult Spondyloarthropathies. Frontiers in Medicine , 8 , Article 681621. 10.3389/fmed.2021.681621. Green open access

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Abstract

Spondyloarthritis (SpA) encompasses a broad spectrum of conditions occurring from childhood to middle age. Key features of SpA include axial and peripheral arthritis, enthesitis, extra-articular manifestations, and a strong association with HLA-B27. These features are common across the ages but there are important differences between juvenile and adult onset disease. Juvenile SpA predominantly affects the peripheral joints and the incidence of axial arthritis increases with age. Enthesitis is important in early disease. This review article highlights the similarities and differences between juvenile and adult SpA including classification, pathogenesis, clinical features, imaging, therapeutic strategies, and disease outcomes. In addition, the impact of the biological transition from childhood to adulthood is explored including the importance of musculoskeletal and immunological maturation. We discuss how the changes associated with adolescence may be important in explaining age-related differences in the clinical phenotype between juvenile and adult SpA and their implications for the treatment of juvenile SpA.

Type: Article
Title: Similarities and Differences Between Juvenile and Adult Spondyloarthropathies
Open access status: An open access version is available from UCL Discovery
DOI: 10.3389/fmed.2021.681621
Publisher version: https://doi.org/10.3389/fmed.2021.681621
Language: English
Additional information: © 2021 Fisher, Ciurtin, Leandro, Sen and Wedderburn. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/).
Keywords: juvenile spondyloarthropathy, enthesitis related arthritis, adolescence, enthesitis, adult spondyloarthropathy
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10128994
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