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An overview and update on bone lesion in craniofacial bones

Connolly, C; Sabarigirivasan, V; Cottone, L; Flanagan, AM; Tirabosco, R; (2021) An overview and update on bone lesion in craniofacial bones. Diagnostic Histopathology , 27 (5) pp. 216-225. 10.1016/j.mpdhp.2021.02.006.

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Abstract

Pathologists infrequently see cases of bone tumours, which are rare entities, and their diagnosis is challenging. To achieve the correct diagnosis and for patients to be offered optimal treatment, it is critical that a multidisciplinary specialised team is involved. The last decade has seen exceptional advances in the molecular classification of bone tumours, which have not only made reaching diagnoses easier, but also makes the subspeciality an exciting area of research. Bone tumours are classified based on their histological features, irrespective of the anatomical site in which the tumour presents; however, not every tumour fits nicely into these categories as some share features. Bone tumours must be diagnosed in the context of the radiology, patient's symptoms, signs and family history. This article reviews key clinical, histologic features of bone tumours and highlights the recent advances made in understanding the pathology of bone lesions in the head and neck region.

Type: Article
Title: An overview and update on bone lesion in craniofacial bones
DOI: 10.1016/j.mpdhp.2021.02.006
Publisher version: http://doi.org/10.1016/j.mpdhp.2021.02.006
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: cancer, craniofacial bones, genetics, mosaicism, sarcoma
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Pathology
URI: https://discovery.ucl.ac.uk/id/eprint/10128899
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