UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Tracing Evolution Through Protein Structures: Nature Captured in a Few Thousand Folds

Bordin, N; Sillitoe, I; Lees, JG; Orengo, C; (2021) Tracing Evolution Through Protein Structures: Nature Captured in a Few Thousand Folds. Frontiers in Molecular Neuroscience , 8 , Article 668184. 10.3389/fmolb.2021.668184. Green open access

[thumbnail of Tracing Evolution Through Protein Structures Nature Captured in a Few Thousand Folds.pdf]
Preview
Text
Tracing Evolution Through Protein Structures Nature Captured in a Few Thousand Folds.pdf - Published Version

Download (2MB) | Preview

Abstract

This article is dedicated to the memory of Cyrus Chothia, who was a leading light in the world of protein structure evolution. His elegant analyses of protein families and their mechanisms of structural and functional evolution provided important evolutionary and biological insights and firmly established the value of structural perspectives. He was a mentor and supervisor to many other leading scientists who continued his quest to characterise structure and function space. He was also a generous and supportive colleague to those applying different approaches. In this article we review some of his accomplishments and the history of protein structure classifications, particularly SCOP and CATH. We also highlight some of the evolutionary insights these two classifications have brought. Finally, we discuss how the expansion and integration of protein sequence data into these structural families helps reveal the dark matter of function space and can inform the emergence of novel functions in Metazoa. Since we cover 25 years of structural classification, it has not been feasible to review all structure based evolutionary studies and hence we focus mainly on those undertaken by the SCOP and CATH groups and their collaborators.

Type: Article
Title: Tracing Evolution Through Protein Structures: Nature Captured in a Few Thousand Folds
Open access status: An open access version is available from UCL Discovery
DOI: 10.3389/fmolb.2021.668184
Publisher version: https://doi.org/10.3389/fmolb.2021.668184
Language: English
Additional information: © 2021 Bordin, Sillitoe, Lees and Orengo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/).
Keywords: bioinformatics and computational biology, protein structural and functional analysis, structural bioinformatics, protein evolution, protein structure classification
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10128819
Downloads since deposit
54Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item