Klinge, T;
Modat, M;
McClelland, JR;
Dimitriadis, A;
Paddick, I;
Hopewell, JW;
Walton, L;
... Ourselin, S; + view all
(2021)
The impact of unscheduled gaps and iso-centre sequencing on the biologically effective dose in Gamma Knife radiosurgery.
J Radiosurg SBRT
, 7
(3)
pp. 213-221.
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213-221 pp RSBRT 465 (Physics Investigation)-hi.pdf - Published Version Download (2MB) | Preview |
Abstract
PURPOSE: Establish the impact of iso-centre sequencing and unscheduled gaps in Gamma Knife® (GK) radiosurgery on the biologically effective dose (BED). METHODS: A BED model was used to study BED values on the prescription iso-surface of patients treated with GK Perfexion™ (Vestibular Schwannoma). The effect of a 15 min gap, simulated at varying points in the treatment delivery, and adjustments to the sequencing of iso-centre delivery, based on average dose-rate, was quantified in terms of the impact on BED. RESULTS: Depending on the position of the gap and the average dose-rate profiles, the mean BED values were decreased by 0.1% to 9.9% of the value in the original plan. A heuristic approach to iso-centre sequencing showed variations in BED of up to 14.2%, relative to the mean BED of the original sequence. CONCLUSIONS: The treatment variables, like the iso-centre sequence and unscheduled gaps, should be considered during GK radiosurgery treatments.
| Type: | Article |
|---|---|
| Title: | The impact of unscheduled gaps and iso-centre sequencing on the biologically effective dose in Gamma Knife radiosurgery. |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| Publisher version: | https://www.oldcitypublishing.com/journals/jrsbrt-... |
| Language: | English |
| Additional information: | Open Access: Licensed under a Creative Commons Attribution 4.0 International License |
| Keywords: | Biologically effective dose (BED), iso-centre sequencing, radiosurgery |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10128757 |
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