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Minimally invasive strategies for the treatment of prostate cancer recurrence after radiation therapy: a systematic review

Mantica, G; Chierigo, F; Suardi, N; Rivas, JG; Kasivisvanathan, V; Papalia, R; Fiori, C; ... Esperto, F; + view all (2020) Minimally invasive strategies for the treatment of prostate cancer recurrence after radiation therapy: a systematic review. Minerva Urologica e Nefrologica , 72 (5) pp. 563-578. 10.23736/S0393-2249.20.03783-2. Green open access

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Abstract

INTRODUCTION: The aim of this review was to conduct a comprehensive analysis of the role of minimally invasive salvage modalities in radio-recurrent prostate cancer and the associated clinical outcomes and toxicity profiles. EVIDENCE ACQUISITION: A systematic review of the current literature was conducted through the Medline and NCBI PubMed, Scopus databases in January 2020. All papers published after 2000, concerning studies conducted on humans for radio-recurrent prostate cancer were considered for the review. EVIDENCE SYNTHESIS: Overall, 545 studies were identified. After duplicate exclusion, initial screening, and eligibility evaluation, a total of 80 studies were included in the qualitative analysis, corresponding to a cohort of 6681 patients. The median age at initial diagnosis ranged from 59 to 75.5. Pre-treatment PSA ranged from 6.2 to 27.4 ng/mL. All patients underwent primary radiotherapy for localized prostate cancer. Cryotherapy, Brachytherapy, EBRT, HIFU were the minimally invasive options mostly used as salvage therapy. They showed to be promising approaches for recurrent prostate cancer (PCa) control, with acceptable toxicities. CONCLUSIONS: Minimally invasive therapeutic options offer promising results in terms of biochemical control in the local recurrence setting. Unfortunately, the absence of high quality and comparative studies makes it difficult to establish which method is the best in terms of oncological and safety outcomes.

Type: Article
Title: Minimally invasive strategies for the treatment of prostate cancer recurrence after radiation therapy: a systematic review
Open access status: An open access version is available from UCL Discovery
DOI: 10.23736/S0393-2249.20.03783-2
Publisher version: http://doi.org/10.23736/S0393-2249.20.03783-2
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Urology & Nephrology, Prostatic neoplasms, Radiotherapy, adjuvant, Cryotherapy, Prostatectomy, INTENSITY FOCUSED ULTRASOUND, ANDROGEN-DEPRIVATION THERAPY, EXTERNAL-BEAM RADIATION, DOSE-RATE BRACHYTHERAPY, DISEASE-FREE SURVIVAL, SALVAGE CRYOTHERAPY, RADICAL PROSTATECTOMY, BIOCHEMICAL FAILURE, PRIMARY RADIOTHERAPY, SEED IMPLANTATION
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention
URI: https://discovery.ucl.ac.uk/id/eprint/10128732
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